Hepatic venous lesions following bone marrow transplantation.

Hepatic failure after bone marrow transplantation.

The article by Beelen et al’ led us to report a case in which the busulfan plus cyclophosphamide preparative regimen for allogeneic bone marrow transplantation terminated in fatal hepatotoxicity. A 31-year-old man with chronic myelogenous leukemia in first chronic phase was bone marrow transplanted from a one DR mismatched donor. Based on encouraging results obtained by Santos et a12 and Tutsch...

ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA

Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...

Pulmonary infiltrates following bone marrow transplantation.

Functional hyposplenism following allogeneic bone marrow transplantation.

AIMS To investigate the incidence of functional hyposplenism in a group of patients who had undergone allogeneic bone marrow transplantation (BMT). METHODS Splenic function was assessed by counting the number of gluteraldehyde fixed red blood cells containing pits or indentations as examined by interference phase microscopy. Normal values are < 2% whereas splenectomy patients have values of 2...

Malignant neoplasms following bone marrow transplantation.

We undertook an analysis of 2,150 recipients of bone marrow transplant (BMT) at the University of Minnesota to determine the incidence of post-BMT malignant neoplasms (MNs). Fifty-one patients developed 53 MNs, compared with 4.3 expected from general population rates (standardized incidence ratio [SIR], 11.6, 95% confidence interval [CI], 8.2-14.5). These included 22 occurrences of B-cell lymph...